Naproxen 500 Tablets : Uses, Benefits, Side Effects, and Safe Dosage Guide

Naproxen 500 mg is one of the most commonly prescribed nonsteroidal anti-inflammatory drugs (NSAIDs) for moderate to severe pain and inflammation. While most over-the-counter (OTC) naproxen products contain only 220 mg per tablet, the 500 mg strength is a prescription-only dosage in both the United States and Canada. It provides stronger pain relief and longer-lasting effects for people managing chronic or intense pain.

In this blog, we’ll break down what Naproxen 500 mg is used for, how it works, who it’s for, and important safety information you need to know.

⭐ What Is Naproxen 500 mg?

Naproxen is an NSAID—a medication that reduces inflammation, relieves pain, and lowers fever. The 500 mg strength is typically prescribed when lower doses (such as OTC 220 mg) are not strong enough.

Brand names may include:

• Naprosyn
• Anaprox
• Aleve (prescription strength)
• Various generics

Naproxen 500 mg tablets are commonly scored, allowing them to be split into 250 mg doses when needed.

⭐ What Conditions Is Naproxen 500 mg Used For?

Doctors often prescribe the 500 mg strength for conditions that require stronger, longer-lasting relief, including:

✔ Arthritis

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis

✔ Musculoskeletal Pain

• Back pain
• Joint injuries
• Tendonitis
• Bursitis
• Sprains and strains

✔ Menstrual Cramps (Dysmenorrhea)

Naproxen is highly effective for period pain because it specifically targets prostaglandins, which contribute to menstrual cramps.

✔ Post-operative or Post-injury Pain

Doctors may prescribe it for short-term pain management after minor surgery or trauma.

⭐ How Does Naproxen 500 mg Work?

Naproxen inhibits COX-1 and COX-2 enzymes, reducing the production of prostaglandins—chemicals responsible for:

• Pain
• Inflammation
• Swelling
• Fever

The 500 mg tablet has a long half-life, which means it provides relief for 8–12 hours, often requiring only 1–2 doses per day.

⭐ Recommended Dosage (Adults)

Always follow your doctor’s instructions, but common dosing patterns include:

• Initial dose: 500 mg
• Maintenance: 250 mg every 6–8 hours or 500 mg twice daily
• Maximum daily limit: Usually 1,000 mg (up to 1,500 mg short-term in certain cases under medical supervision)

Because Naproxen 500 mg is powerful, it is not intended for long-term misuse or self-adjusted dosing.

⭐ Side Effects You Should Watch For

As with all NSAIDs, Naproxen can cause side effects, especially when taken at higher doses.

Common Side Effects

• Heartburn
• Stomach pain
• Nausea
• Headache
• Dizziness

Serious (Seek medical help)

• Gastrointestinal bleeding
• Ulcers
• Kidney problems
• Increased blood pressure
• Swelling of legs or ankles

If you have heart, kidney, or stomach issues, your doctor may recommend a lower dose or different medication.

⭐ Who Should Not Take Naproxen 500 mg?

Avoid Naproxen 500 mg unless prescribed if you have:

• History of GI bleeding or ulcers
• Severe kidney disease
• Heart failure or recent heart attack
• Aspirin-sensitive asthma
• Pregnancy in the 3rd trimester

NSAIDs can interact with blood thinners, diuretics, ACE inhibitors, SSRIs, and more—so always tell your doctor about other medications.

⭐ Tips for Safe Use

To reduce the risk of side effects:

✔ Take with food

This helps protect the stomach lining.

✔ Stay hydrated

Naproxen can stress the kidneys if you’re dehydrated.

✔ Avoid mixing with other NSAIDs

Do not combine with ibuprofen, aspirin (unless advised), or diclofenac.

✔ Limit alcohol

Alcohol increases the risk of stomach bleeding.

✔ Use the lowest effective dose

Only take more if advised by your healthcare provider.

⭐ OTC vs Prescription Naproxen (What’s the Difference?)

The 500 mg version is usually chosen when OTC options are insufficient.

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