Daratumumab 400 injection

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Daratumumab 400 Injection: Uses, Dosage, Side Effects, and Availability

Introduction

Daratumumab 400 injection, marketed under the brand name Darzalex 400, is a revolutionary monoclonal antibody used in the treatment of multiple myeloma. It works by targeting the CD38 protein on myeloma cells, leading to their destruction. This blog provides an in-depth look at Daratumumab’s uses, dosage, side effects, and its availability in the USA, Canada, EU, India, Arab nations, and Australia.

What is Daratumumab 400 Injection?

Daratumumab is a monoclonal antibody that belongs to a class of immunotherapy drugs. It enhances the body’s immune system to fight cancer cells and is commonly used alone or in combination with other therapies.

Key Benefits:

  • Effective for relapsed or refractory multiple myeloma
  • Works well alone or in combination with other cancer treatments
  • Approved by the FDA, EMA, and other health authorities worldwide

Uses of Daratumumab 400 Injection

Daratumumab is primarily used in the treatment of multiple myeloma, a type of blood cancer. It is administered to patients who:

  • Have received at least one prior therapy for multiple myeloma
  • Have relapsed or refractory multiple myeloma
  • Are undergoing newly diagnosed treatment regimens

It is often combined with lenalidomide, bortezomib, dexamethasone, or other chemotherapeutic agents to improve effectiveness.

Daratumumab 400 Injection Dosage and Administration

Daratumumab is typically administered as an intravenous (IV) infusion or a subcutaneous (SC) injection. The dosage varies depending on the patient’s condition and medical history.

Standard Dosage Guidelines:

  • Initial dose: 16 mg/kg administered weekly for the first 8 weeks
  • Maintenance dose: Every 2 weeks for 16 weeks, then once a month
  • Subcutaneous Injection: 1,800 mg administered over a few minutes instead of hours (as IV infusion requires)

The exact dosage and frequency should be determined by a healthcare provider based on the patient’s medical condition.

Side Effects of Daratumumab 400 Injection

While Daratumumab is highly effective, it may cause certain side effects. Some common and severe side effects include:

Common Side Effects:

  • Fatigue
  • Nausea
  • Fever
  • Back pain
  • Respiratory infections

Serious Side Effects:

  • Infusion-related reactions (IRRs): Can include fever, chills, difficulty breathing
  • Low blood cell count: May lead to anemia or increased infection risk
  • Liver enzyme elevation: Should be monitored through regular blood tests
  • Allergic reactions: Rash, swelling, or severe itching

Patients should inform their doctor immediately if they experience severe side effects.

 

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