Lorlatinib Tablets 25 mg : Uses, Dosage, Side Effects & Precautions

Introduction

Lorlatinib Tablets 25 mg are a targeted anti-cancer medication primarily used in the treatment of certain types of lung cancer. It belongs to a class of drugs known as kinase inhibitors, which work by blocking abnormal proteins that promote cancer cell growth. This medicine is usually prescribed when other treatments have failed or stopped working.

What is Lorlatinib Tablets 25 mg ?

Lorlatinib is an oral medication used to treat ALK-positive metastatic non-small cell lung cancer (NSCLC). It specifically targets cancer cells with an abnormal anaplastic lymphoma kinase (ALK) gene, helping to slow or stop their growth. (Drugs.com)

It is commonly available in different strengths, including 25 mg tablets, which may be used for dose adjustments or specific treatment plans.

Uses of Lorlatinib Tablets 25 mg

Lorlatinib tablets are prescribed for:

• Treatment of ALK-positive non-small cell lung cancer
• Cancer that has spread to other parts of the body (metastatic)
• Patients who have not responded well to previous ALK inhibitor therapies

The drug works by inhibiting enzymes responsible for cancer cell multiplication, thereby controlling disease progression. (Cleveland Clinic)

How Lorlatinib Tablets 25 mg Works

Lorlatinib blocks the activity of ALK proteins that drive tumor growth. By inhibiting these proteins, it helps:

• Prevent cancer cells from multiplying
• Slow tumor growth
• Reduce the spread of cancer in the body

Dosage and Administration

• The usual adult dose is 100 mg once daily, but doctors may adjust the dose based on patient condition and tolerance. (Drugs.com)
• The 25 mg tablet is often used for dose modification or in combination with other strengths.
• Take the tablet once daily at the same time, with or without food.
• Swallow whole; do not crush or chew.

Missed Dose:

• Take as soon as remembered unless it is close to the next dose.
• Do not double the dose.

Common Side Effects

Some patients may experience mild to moderate side effects, including:

• Fatigue
• Diarrhea
• Weight gain
• Joint pain
• Swelling in hands or feet (Cleveland Clinic)

Serious Side Effects

Seek medical attention if you notice:

• Mood changes, depression, or confusion
• Difficulty breathing or persistent cough
• Irregular heartbeat
• High blood sugar symptoms
• Vision changes or neurological symptoms (Cleveland Clinic)

Precautions and Warnings

Before taking Lorlatinib, inform your doctor if you have:

• Heart disease or irregular heartbeat
• Liver or lung disorders
• High cholesterol or diabetes
• History of depression or seizures (Cleveland Clinic)

Important precautions:

• Avoid grapefruit or grapefruit juice
• Do not use during pregnancy (can cause birth defects)
• Use effective contraception during treatment
• Regular blood tests may be required to monitor cholesterol and sugar levels

Drug Interactions

Lorlatinib may interact with several medications, including:

• Certain antibiotics and antifungals
• Anti-seizure medications
• Herbal supplements like St. John’s Wort

Always inform your healthcare provider about all medicines you are taking.

Storage Instructions

• Store at room temperature
• Keep away from moisture and heat
• Keep out of reach of children

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